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Shingles quick look
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This chart rates treatment options according to general effectiveness, ease of use,
side effects and safety.
Valtrex/valacyclovir
(Treatment of Shingles Symptoms)
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Good
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Newer antiviral pill. Effective. May be slightly more effective then acyclovir. Taken 3 times a day. Less expensive than other newer antiviral (Famvir), but much more expensive than generic acyclovir.
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Valtrex/valacyclovir
Treatment with antiviral pills (Valtrex, Famvir, or generic acyclovir) results in reduced pain and faster healing in individuals with shingles.
Valaciclovir (Valtrex) is a newer antiviral that is similar to acyclovir (Zovirax) for treating shingles symptoms, but appears to be superior for shortening the shingles duration and for preventing postherpetic neuralgia (pain that lasts after the rash is gone).
Acyclovir is taken 5 times a day for 7 to 10 days, while valaciclovir (Valtrex) is taken 3 times a day for 7 days.
Valaciclovir (Valtrex) is much less expensive than another newer antiviral called famciclovir (Famvir), although they are similar in effectiveness.
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Famvir/famciclovir
(Treatment of Shingles Symptoms)
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Good
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Newer antiviral pill. Effective. May be more effective then acyclovir. Taken 3 times a day. Expensive.
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Famvir/famciclovir
Treatment with antiviral pills (Famvir, Valtrex, or generic acyclovir) results in reduced pain and faster healing in patients with shingles.
Famciclovir (Famvir) is a newer antiviral that is similar to acyclovir (Zovirax) for treating shingles symptoms, but appears to be superior for shortening the shingles duration and for preventing postherpetic neuralgia (pain that lasts after the rash is gone).
Acyclovir is taken 5 times a day for 7 to 10 days, while famciclovir (Famvir) is taken 3 times a day for 7 days.
Famciclovir (Famvir) is much more expensive than another newer antiviral called valaciclovir (Valtrex), although they are similar in effectiveness.
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Wet dressings and compresses (Burrow's solution, Domeboro's soaks, tincture of benzoin and/or flexible collodion, alcohol, menthol and/or phenol, more)
(Treatment of Shingles Symptoms)
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Good
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Applied to shingles rash. Thought to provide modest symptom relief. Safe. No side effects.
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Wet dressings and compresses (Burrow's solution, Domeboro's soaks, tincture of benzoin and/or flexible collodion, alcohol, menthol and/or phenol, more)
Experts consider the application of cool compresses and soaks (particularly those that dry out the rash) to be modestly effective for symptoms relief of shingles.
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Tricyclic Antidepressants (Elavil/amitriptyline, Pamelor/nortriptyline, Anafranil/clomipramine, more)
(Treatment once Postherpetic Neuralgia Develops)
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Good
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The mainstay of treatment for postherpetic neuralgia. Effective. Relieves pain within 1 to 2 weeks for many patients. Common side effects - especially in older patients.
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Tricyclic Antidepressants (Elavil/amitriptyline, Pamelor/nortriptyline, Anafranil/clomipramine, more)
Tricyclic antidepressants (amitriptyline, Elavil, nortriptyline, Aventyl, Pamelor, desipramine, Pertofrane, Norpramin, more) are the most commonly prescribed treatment for patients with postherpetic neuralgia (pain that lasts after shingles heal). They are sometimes prescribed along with other medications such as a phenothiazine (perphenazine, Trilafon, fluphenazine, Permitil, thioridazine, Mellaril, more).
Tricyclic antidepressants provide pain relief within 1 to 2 weeks for many patients.
There is some evidence to suggest that the tricyclic antidepressant, nortriptyline (Aventyl, Pamelor), and desipramine (Pertofrane, Norpramin) may cause fewer side effects than amitriptyline (Elavil).
Tricyclic antidepressants have also been prescribed along with anti-seizure medications (carbamazapine, Tegretol, phenytoin, Dilantin). Studies have specifically evaluated combining the anti-seizure medication, carbamazapine (Tegretol), with different tricyclic antidepressants including nortriptyline (Aventyl, Pamelor) or clomipramine (Anafranil), and found conflicting results.
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Neurontin/gabapentin, Lyrica/pregabalin
(Treatment once Postherpetic Neuralgia Develops)
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Good
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An anti-seizure medication which has recently been used for postherpetic neuralgia. Effective. Fewer side effects than tricyclic antidepressants (Elavil, etc).
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Neurontin/gabapentin, Lyrica/pregabalin
Studies suggest that Gabapentin (Neurontin), a medication that has recently been approved for the treatment of postherpetic neuralgia (pain that lasts after shingles heals), may be as effective as tricyclic antidepressants and may cause fewer side effects.
Side effects include: sleepiness, dizziness, trouble with balance, leg swelling, and susceptibility to infection.
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Valtrex/valacyclovir
(Prevention of Postherpetic Neuralgia)
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Good
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Newer antiviral pill. Effective for shingles symptoms and for preventing postherpetic neuralgia (pain that lasts after shingles heals). May be more effective then acyclovir. Taken 3 times a day. Less expensive than other new antiviral (Famvir).
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Valtrex/valacyclovir
Treatment with antiviral pills results in faster healing of shingles and decreases the chance of developing postherpetic neuralgia (pain that lasts after shingles heals).
Valaciclovir (Valtrex) is a newer antiviral that is as effective as acyclovir (Zovirax) for treating shingles symptoms, but appears to be superior for shortening the duration of shingle and for preventing postherpetic neuralgia.
Acyclovir is taken 5 times a day for 7 to 10 days, while valaciclovir (Valtrex) is taken 3 times a day for 7 days.
Valaciclovir (Valtrex) is much less expensive than another newer antiviral called famciclovir (Famvir) although they are similar in effectiveness.
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Early Treatment of Shingles with Antiviral Medications
(Prevention of Postherpetic Neuralgia)
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Good
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Early treatment (within the first 24 to 72 hours) is most effective for treating shingles symptoms and for preventing postherpetic neuralgia (pain that lasts after shingles heals).
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Early Treatment of Shingles with Antiviral Medications
Early treatment (within the first 24 to 72 hours of the first sign of a rash) with antiviral medications (acyclovir, Zovirax, famciclovir, Famvir, valaciclovir, Valtrex) reduces pain caused by shingles, decreases the time it takes for shingles to heal, and may decrease the chance of developing postherpetic neuralgia (pain that lasts after shingles heals).
Although early treatment with antivirals is thought to be preferable, experts recommend treatment with antiviral medications after 72 hours as well if the rash is not yet completely crusted, especially for patients older than age 50.
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Zovirax/acyclovir
(Treatment of Shingles Symptoms)
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Good
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Antiviral pill. Effective for treatment of shingles. Until recently, the most commonly prescribed antiviral. Few side effects. Must be taken 5 times a day.
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Zovirax/acyclovir
Treatment with antiviral pills results in reduced pain and faster healing in patients with shingles.
Acyclovir (Zovirax) was, until recently, the most frequently prescribed antiviral. It is well-tolerated and causes few side effects.
Early treatment (within 24 to 48 hours of first experiencing symptoms) seems to be most effective.
Valaciclovir (Valtrex) and famciclovir (Famvir) are newer antivirals that are similar to acyclovir (Zovirax) for treating shingles symptoms, but appear to be superior for shortening the shingles duration and for preventing postherpetic neuralgia.
Acyclovir is taken 5 times a day for 7 to 10 days, while valaciclovir (Valtrex) and famciclovir (Famvir) are taken 3 times a day for 7 days.
Acyclovir (Zovirax), given intravenously, is the drug of choice for serious herpes zoster infections.
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Famvir/famciclovir
(Prevention of Postherpetic Neuralgia)
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Fair
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Newer antiviral pill. Effective for both shingles symptoms and for preventing postherpetic neuralgia (pain that lasts after shingles heals). May be more effective then acyclovir. Taken 3 times a day. Expensive.
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Famvir/famciclovir
Treatment with antiviral pills results in faster healing of shingles and decreases the chance of developing postherpetic neuralgia (pain that lasts after shingles heals).
Famciclovir (Famvir) is a newer antiviral that is as effective as acyclovir (Zovirax) for treating shingles symptoms, but appears to be superior for shortening the duration of shingles and for preventing postherpetic neuralgia.
Acyclovir is taken 5 times a day for 7 to 10 days, while famciclovir (Famvir) is taken 3 times a day for 7 days.
Famciclovir (Famvir) is much more expensive than another newer antiviral called valaciclovir (Valtrex), although they are similar in effectiveness.
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Zostrix/capsaicin
(Treatment once Postherpetic Neuralgia Develops)
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Fair
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Applied to the skin. May result in completely relief in 25%, and partial relief in 80% of patients. May cause a burning sensation that makes it difficult to use. Should not be applied to shingles rash.
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Zostrix/capsaicin
Capsaicin (Zostrix) is a cream that is applied to the skin. It relieves pain in approximately 25%, and improves pain in 80% of patients with postherpetic neuralgia.
A disadvantage of this medication is that it may irritate the skin in some patients and cause a burning sensation. Applying a topical "numbing" medicine to the skin before using the capsaicin may help.
Capsaicin should not be applied to a shingles rash. It is only recommended for treating postherpetic neuralgia (pain that lasts after shingles heals).
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Zovirax/acyclovir
(Prevention of Postherpetic Neuralgia)
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Fair
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Antiviral pills. Effective for shingles symptoms and for preventing postherpetic neuralgia (pain that lasts after shingles heals). Until recently, the most commonly prescribed antiviral. Few side effects. Must be taken 5 times a day.
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Zovirax/acyclovir
Treatment with antiviral pills results in faster shingles healing and decreases the chance of developing postherpetic neuralgia (pain that lasts after shingles heals).
Acyclovir (Zovirax), previously the most commonly prescribed antiviral, is well-tolerated and causes few side effects.
Valaciclovir (Valtrex) and famciclovir (Famvir) are newer antivirals that are as effective as acyclovir (Zovirax) for shingles symptoms, but appear to be superior for preventing postherpetic neuralgia (pain that lasts after shingles heals).
Acyclovir is taken 5 times a day for 7 to 10 days, while valaciclovir (Valtrex) and famciclovir (Famvir) are taken 3 times a day for 7 days. Early treatment (within 24 to 48 hours of first experiencing symptoms) seems to be most effective.
Acyclovir (Zovirax), given intravenously, is the drug of choice for serious herpes zoster infections.
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Prevention of Shingles with Adult Vaccination
(Zostavax/Herpes Zoster vaccine for adults age 60 and above)
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Not available
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This vaccine is now recommended for all adults at or over age 60, whether or not they've ever had chickenpox or previously had the chicken pox (varicella) vaccine.
Zostavax is a new vaccine that helps to reduce the risk of getting herpes zoster (shingles) in individuals 60 years of age and older. The virus that causes chickenpox can remain in the body for many years afterwards and sometimes reactivates to cause shingles.
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Prevention of Shingles with Adult Vaccination
Anyone who has had chicken pox is at risk for developing shingles. It is estimated that 1 million or more cases occur each year in the United States. Shingles can occur in people of all ages, but most commonly in those over 60 years of age, and this risk increases as people get older. When shingles develop, a rash or blisters appear on the skin, generally on one side of the body. This is a sign that the virus, that has been dormant (asleep) in the nerve cells, has reactivated and traveled on a path from the nerves to the skin.
Because the nerves along the path become inflamed, shingles can also be painful. Pain that lasts for months after the rash has healed is called post herpetic neuralgia or PHN. For some people, this pain can be severe and chronic.For more information about this new vaccine, the FDA webite has useful information and can be found at http://www.fda.gov/CbER/products/zosmer052506qa.htm
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Sinemet/Levodopa & carbidopa
(Treatment of Shingles Symptoms)
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Fair
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Some evidence suggesting effectiveness for shingles symptoms. Insufficient data about effectiveness for preventing postherpetic neuralgia.
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Sinemet/Levodopa & carbidopa
Levodopa and carbidopa are usually used to treat Parkinson's disease. Some experts report good results for treating the symptoms of shingles and for promoting more rapid recovering in elderly patients with shingles.
There is insufficient data about whether treatment with levodopa or carbidopa reduces the chance of developing postherpetic neuralgia.
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Bandages or Splints
(Treatment of Shingles Symptoms)
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Fair
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Protects the rash from rubbing against clothing. Tighter bandages can splint the area and decrease pain by limiting movement.
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Bandages or Splints
Some experts recommend the use of a bandage (that may also act as a splint) to protect the affected area and to restrict its movement and decrease pain.
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Numbing Medications Applied to the Skin (Lidocaine Patches, EMLA cream)
(Treatment once Postherpetic Neuralgia Develops)
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Fair
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Applied to the skin. May be effective for relieving the pain of postherpetic neuralgia. More study data needed.
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Numbing Medications Applied to the Skin (Lidocaine Patches, EMLA cream)
Some experts believe that "numbing medications" (anesthetics) that are applied to the skin may decrease the pain of postherpetic neuralgia (pain that lasts after shingles heals).
Studies data are not available to confirm whether or not numbing medications work, but some experts believe that it is helpful.
These medications may not be recommend for use on the face.
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Transcutaneous Nerve Stimulation (TENS)
(Treatment once Postherpetic Neuralgia Develops)
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Fair
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Small electrical stimulation applied to the area affected by postherpetic neuralgia. Considered effective for patients who do not find sufficient relief with other treatments.
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Transcutaneous Nerve Stimulation (TENS)
TENS is a treatment which is often used for chronic pain. With TENS, a small electrical stimulation is applied to an area of skin through a patch that sits on the skin. TENS is often recommended for patients whose postherpetic neuralgia is not sufficiently controlled by other treatments alone.
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Opiates/Narcotics (oxycodone, OxyContin/oxycodone, codeine, Darvon/propoxyphene, Vicodin/hydrocodone, morphine, methadone, more)
(Treatment of Shingles Symptoms)
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Fair
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May be necessary on a short-term basis to control severe pain.
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Opiates/Narcotics (oxycodone, OxyContin/oxycodone, codeine, Darvon/propoxyphene, Vicodin/hydrocodone, morphine, methadone, more)
Pain medications/narcotics may be necessary to control pain during shingles. Long-term use of narcotics is not recommended. In some cases, however, narcotics may be the only available choice if all other options fail. If these medications are necessary, they should be used with great care and, preferably, under direction of a pain center.
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Referral to a Pain Clinic
(Treatment once Postherpetic Neuralgia Develops)
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Good
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Recommended for patients whose symptoms do not improve with usual treatments.
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Referral to a Pain Clinic
Pain clinics, which are typically located at major medical centers, specialize in "difficult to treat" pain problems. Experts recommend referral to a pain clinic for all patients, whenever possible, if postherpetic neuralgia fails to improve sufficiently despite appropriate use of the usual treatments, especially if narcotic medications are prescribed.
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Foscavir/foscarnet
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Fair
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Effective for treating shingles. Used when other antivirals are not effective against shingles.
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Foscavir/foscarnet
Foscarnet is sometimes recommended to treat shingles that are "resistant" (insensitive) to antiviral medications (acyclovir, Zovirax, famciclovir, Famvir, valaciclovir, Valtrex).
Foscarnet is used to treat resistant herpes zoster infections (shingles) in patients who are positive for HIV, or who have AIDS.
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Steroid Pills
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Fair
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Not routinely recommended but may be used for special circumstances such as facial swelling due to shingles.
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Steroid Pills
Some experts recommend steroid pills for patients with severe facial swelling due to shingles to decrease swelling and pain.
Steroid pills are usually prescribed for 3 to 4 weeks.
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Steroid and Pain Medication Injections
(Treatment of Shingles Symptoms)
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Fair
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Daily injections. Sometimes recommended for severe pain if other treatments fail.
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Steroid and Pain Medication Injections
Steroids may be directly injected into the shingles rash to decrease pain. Injections are typically performed on a daily basis.
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Steroid and Pain Medication Injections
(Treatment once Postherpetic Neuralgia Develops)
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Fair
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Daily injections required. Sometimes recommended for severe pain if other treatments fail.
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Steroid and Pain Medication Injections
Steroids may be directly injected into the area of discomfort to decrease pain. This treatment is typically performed on a daily basis.
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Topical Zovirax/acyclovir
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Not available
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May promote faster healing of shingles in patients who have immune system problems. Little effect on pain or postherpetic neuralgia. Applied every 4 hours.
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Topical Zovirax/acyclovir
There is some data to suggest that topical acyclovir (acyclovir that is applied to the skin) may promote faster healing of shingles for patients who have immune (infection fighting) system problems.
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Netivudine
(Treatment of Shingles Symptoms)
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Poor
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An antiviral drug. Less effective than acyclovir in one large study. Not commonly recommended.
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Netivudine
Netivudine is another antiviral medication like acyclovir that has been used to treat shingles. In a recent, large study, however, acyclovir was significantly more effective than netivudine for controlling pain.
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Interferon Alfa
(Treatment of Shingles Symptoms)
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Poor
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Somewhat effective. Common, significant side effects.
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Interferon Alfa
Although somewhat effective for shingles treatment, interferon alfa is not usually recommended because of frequently occurring, significant side effects.
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Steroid Pills
(Treatment of Shingles Symptoms)
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Poor
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No longer routinely recommended. Less effective than antivirals and more side effects.
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Steroid Pills
Steroid pills were commonly used in the past to treat shingles. They are no longer routinely recommended since the newer antiviral drugs are more effective.
Studies have evaluated the combination of steroids and antiviral drugs and have found that combining the drugs did not improve long-term results or decrease the chance of developing postherpetic neuralgia.
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Opiates/Narcotics: OxyContin/oxycodone, codeine, Darvon/propoxyphene, Vicodin/hydrocodone, morphine, methadone, more
(Treatment once Postherpetic Neuralgia Develops)
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Poor
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Can lead to problems with drug overuse and addiction when used for extended periods of time.
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Opiates/Narcotics: OxyContin/oxycodone, codeine, Darvon/propoxyphene, Vicodin/hydrocodone, morphine, methadone, more
Narcotics are not generally recommended for postherpetic neuralgia. Treatment for this condition often last an extended period of time, and the use of narcotics for a long time has led to problems with drug dependence and addiction in many patients.In occasional, severe situations, these medications may be necessary, but should be used with great care and, preferably, under direction of a pain center.
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Emetine and Dehydroemetine
(Treatment of Shingles Symptoms)
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Very poor
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Some data suggesting effectiveness for treating shingles symptoms. Potential for serious side effects, including heart damage, limit usefulness.
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Emetine and Dehydroemetine
There is evidence to suggest that emetine and dehydroemetine may decrease shingles symptoms. Because they can cause serious heart problems, these medications are not routinely used for shingles treatment.
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Antipsychotic Drugs: (Haldol/haloperidol, Prolixin/fluphenazine, more)
(Treatment once Postherpetic Neuralgia Develops)
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Not available
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Further investigation necessary. Frequent side effects.
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Antipsychotic Drugs: (Haldol/haloperidol, Prolixin/fluphenazine, more)
There is some evidence to suggest that a short course (4 to 10 days) of chlorprothixene (Taractan) may be effective for relieving the pain of postherpetic neuralgia. Data is limited and further investigation is necessary.
Chlorprothixene (Taractan) should be prescribed in low doses since the higher doses often cause side effects.
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Surgical/Freezing (Cryotherapy) Procedures
(Treatment once Postherpetic Neuralgia Develops)
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Not available
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Treatments of last resort. For severe cases of postherpetic neuralgias that don't respond to other treatments.
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Surgical/Freezing (Cryotherapy) Procedures
Several types of procedures have been attempted for severe symptoms that don't improve with other treatments.
Cryotherapy is a procedure in which painful areas are "frozen".
Some surgical procedures involve interrupting the nerves that provide sensation to the skin. Most have yielded disappointing results.
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