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Hibiclens (chlorhexidine topical)

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Hibiclens may cause the following symptoms that are related to occupational contact dermatitis - an allergic reaction caused by work-related exposure to substances:

Medical Source Information
Yellow highlights indicate symptoms related to occupational contact dermatitis - an allergic reaction caused by work-related exposure to substances.

Hypersensitivity reactions to chlorhexidine have included allergic contact dermatitis, pruritus, vesicle formation, urticaria, dyspnea, and anaphylactic shock.

Hypersensitivity reactions have been reported after the use of products containing chlorhexidine as a preservative or devices coated with chlorhexidine, including allergic contact balanitis and anaphylactic shock. Patch testing using chlorhexidine has revealed positive reactions in more than 2% of patients tested. In eczema patients, the rate may be as high as 5%.

If you experience a rare but serious allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; hives; or a rash), stop using chlorhexidine topical and seek emergency medical attention or contact your doctor immediately. Occasionally, mild skin irritation may occur. Continue to use chlorhexidine topical and talk to your doctor if you experience skin irritation. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Ocular side effects associated with chlorhexidine cleanser have included ocular toxicity. Ocular side effects associated with chlorhexidine containing contact lens solutions have rarely included allergic conjunctivitis.

Exposure of the eye to chlorhexidine cleanser, generally during preparation for facial surgery, has resulted in eye pain, edema of the epithelium, keratitis, inflammation of the conjunctiva, corneal epithelial cell loss, chronic corneal ulcers, and opacification. Corneal transplantation to correct permanent damage has been required in some patients. Allergic conjunctivitis is rarely associated with the use of contact lens solutions which contain low concentrations of chlorhexidine as a preservative.

References

Conjunctivitis due to soft lens solutions. van Ketel WG, Melzer-van Riemsdijk FA Contact Dermatitis 1980;6:321-4.
Hibiclens keratitis. Shore JW Am J Ophthalmol 1987;104:670-1.
Corneal damage due to eye contact with chlorhexidine gluconate. Tabor E, Bostwick DC, Evans CC JAMA 1989;261:557-8.
Corneal edema related to accidental Hibiclens exposure. Phinney RB, Mondino BJ, Hofbauer JD, Meisler DM, Langston RH, Forstot SL, Benes SC Am J Ophthalmol 1988;106:210-5.

Multum version: 154.0 (Jun 16, 2010)

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