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Hibiclens (chlorhexidine topical)

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Hibiclens may cause the following symptom that is related to skin peeling/scaling/flaking:

Skin flaking/peeling (rare)

Medical Source Information
Yellow highlights indicate symptoms related to skin peeling/scaling/flaking.

Gastrointestinal side effects have been reported the most frequently with chlorhexidine oral rinses. These have included staining of teeth and tongue, increased calculus formation, alteration of taste perception, bitter taste, burning, numbness, dryness, and soreness. Aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum have been reported rarely with chlorhexidine oral rinses. Gastrointestinal side effects associated with chlorhexidine oral rinses without oral hygiene measures have included increased gingival bleeding after gentle massage. Parotid gland swelling has been reported rarely. Gastrointestinal side effects associated with chlorhexidine cleanser have included a single case report of acute gastritis. Gastrointestinal side effects associated with chlorhexidine cleanser enema have included a single case report of acute colitis. Gastrointestinal side effects associated with the periodontal chip have included transient toothache (50.7% vs 41.4% placebo), including dental, gingival, or oral pain, tenderness, aching, throbbing, soreness, discomfort, and sensitivity.

References

Side-effects and patient acceptance of 0.2% versus 0.1% chlorhexidine used as post-operative prophylactic mouthwash. Hepso HU, Bjornland T, Skoglund LA Int J Oral Maxillofac Surg 1988;17:17-20.
Gingival bleeding after chlorhexidine rinses with or without mechanical oral hygiene. Asikainen S, Sandholm L, Sandman S, Ainamo J J Clin Periodontol 1984;11:87-94.
Gingival bleeding after chlorhexidine mouthrinses. Ainamo J, Asikainen S, Paloheimo L J Clin Periodontol 1982;9:337-45.
Safety of Hibitane. II. Human experience. Rushton A J Clin Periodontol 1977;4:73-9.
Desquamative mucosal reactions due to chlorhexidine gluconate. Report of 3 cases. Skoglund LA, Holst E Int J Oral Surg 1982;11:380-2.
Colitis after Hibiclens enema. Hardin RD, Tedesco FJ J Clin Gastroenterol 1986;8:572-5.
Product Information. Peridex (chlorhexidine). Anonymous Procter and Gamble Pharmaceuticals, Cincinnati, OH. PROD;
Chlorhexidine-induced gastritis. Roche S, Chinn R, Webb S Postgrad Med J 1991;67:210-1.

Multum version: 154.0 (Jun 16, 2010)

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