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Testopel Pellets (testosterone)

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Testopel Pellets may cause discomfort/burning sensation in 3% of people.

This drug may also cause the following symptoms that are related to discomfort/burning sensation:


Medical Source Information
Yellow highlights indicate symptoms related to discomfort/burning sensation.

Dermatologic side effects have included hirsutism, acne, male-patterned baldness and seborrhea. Dermal reactions have been the most commonly reported side effects for transdermal testosterone and occur primarily at the site of application. Dermal effects have included 3 types: irritation including mild to moderate erythema (to 6%), induration (3%), itching (12%), and burning (3%); allergic contact dermatitis including pruritus (to 37%), vesicles (6%), and rash (2%); and burn-like blisters (12%).

Discontinuation rates for transdermal testosterone were as follows: due to chronic skin irritation (5%), allergic dermal reactions (4%), and burn-like, usually a single site (0%). Triamcinolone 1% cream applied sparingly to skin under the reservoir reduced irritation and did not interfere with testosterone absorption. Ointment formulations reduce testosterone absorption.

Local side effects have included inflammation and pain at injection or dermal application site.

Metabolic side effects have included osteolytic-induced hypercalcemia in immobilized patients or those with metastatic breast disease. Increased cholesterol levels and acute intermittent porphyria have been reported.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using testosterone topical and call your doctor at once if you have any of these serious side effects: burn-like blistering of the skin where the transdermal patch is worn; skin irritation with patch-wearing that does not get better with time; problems with urination; swelling of your ankles; frequent, prolonged, or bothersome erections; or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Topical testosterone is absorbed through the skin and can cause symptoms of male features in a woman or child who comes into contact with the medication. Call your doctor if your female partner has male-pattern baldness, excessive body hair growth, increased acne, irregular menstrual periods, or any other signs of male characteristics. Less serious side effects may include: redness, itching, burning, or hardened skin where the skin patch is worn; breast swelling or tenderness; increased acne or hair growth; headache, depressed mood; or changes in your sex drive. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lab and Diagnostic Tests
If certain symptoms develop, ask your physician whether you need the following lab tests or other diagnostic tests (if you've not already had them):
  • Monitor testosterone
References
  1. Acne in pubertal boys undergoing treatment with androgens. Fyrand O, Fiskaadal HJ, Trygstad O Acta Derm Venereol 1992;72:148-9.
  2. Contact allergy to a testosterone patch. Buckley DA, Wilkinson SM, Higgins EM Contact Dermatitis 1998;39:91-2.
  3. Effects of testosterone enanthate in normal men: experience from a multicenter contraceptive efficacy study. World Health Organizatio Task Force on Methods for the Regulation of Male Fertility. Wu FC, Farley TM, Peregoudov A, Waites GM Fertil Steril 1996;65:626-36.
  4. Iatrogenic causes of hirsutism. Bates GW, Cornwell CE Clin Obstet Gynecol 1991;34:848-51.
  5. A burn-like lesion caused by a testosterone transdermal system. Bennett NJ Burns 1998;24:478-80.
  6. Clinical experience using the Androderm (R) testosterone transdermal system in hypogonadal adolescents and young men with beta-thalassemia major. DeSanctis V, Vullo C, Urso L, Rigolin F, Cavallini A, Caramelli K, Daugherty C, Mazer N J Pediatr Endocrinol Metab 1998;11:891-900.
  7. Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA J Clin Endocrinol Metab 1999;84:3469-78.
  8. Product Information. Androderm (testosterone topical). Anonymous SmithKline Beecham, Philadelphia, PA. PROD;
  9. Exacerbation of psoriasis precipitated by an oestradiol-testosterone implant. O'Driscoll JB, August PJ Clin Exp Dermatol 1990;15:68-9.
  10. Acne of the fulminans type following testosterone therapy in three excessively tall boys. Traupe H, von Muhlendahl KE, Bramswig J, Happle R Arch Dermatol 1988;124:414-7.
Multum version: 154.0 (Jun 16, 2010)
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