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Savella (milnacipran)

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Savella may cause decreased appetite.

This drug may also cause the following symptoms that are related to decreased appetite:

Medical Source Information
Yellow highlights indicate symptoms related to decreased appetite.

Psychiatric side effects including insomnia (12%), anxiety (4%), depression, stress, anorexia, delirium, and hallucination have been reported.

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have any of these serious side effects: fast or pounding heartbeats; painful or difficult urination; easy bruising or bleeding, nosebleeds, bloody or tarry stools, coughing up blood; confusion, hallucinations, severe weakness, seizure (convulsions); high fever, sweating, chills or goose bumps, memory problems, trouble concentrating, loss of coordination, overactive reflexes, vomiting, diarrhea; high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats); or stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: constipation; dry mouth, nausea, stomach pain, heartburn, bloating; dizziness, drowsiness, headache, tired feeling; stuffy nose, sneezing, or other cold symptoms; sleep problems (insomnia); swelling in your hands or feet; hot flashes, sweating, itching, mild skin rash; numbness or tingling; blurred vision; or decreased sex drive, impotence, or difficulty having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Gastrointestinal side effects including nausea (37%), constipation (16%), vomiting (7%), dry mouth (5%), abdominal pain (3%), decreased appetite (2%), diarrhea, dyspepsia, gastroesophageal reflux disease, flatulence, and abdominal distension have been reported.

Side Effects to Watch
Watch closely for the following side effects and notify your physician immediately should any of these develop:

Abnormal bruising or signs of bleeding such as bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash (signs of problems with blood clot formation)

Lab and Diagnostic Tests
If certain symptoms develop, ask your physician whether you need the following lab tests or other diagnostic tests (if you've not already had them):

Blood pressure - whenever dose is increased
Blood pressure - periodically
Blood tests to assess normal clotting - in people who develop signs of bleeding such as abnormal bruising or signs of bleeding including bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash
Blood pressure - when the drug is first started
Monitor blood tests
Monitor serotonin and serotonin

Multum version: 154.0 (Jun 16, 2010)

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Most Frequent Side Effects

Frequent User Reported Side Effects

(8)	Constipation
(3)	Nausea
(3)	Lack of energy/fatigue
(3)	Chills
(3)	Numbness/tingling in fingers
(2)	Painful urination
(2)	Cold feet or hands
(2)	Flushed skin

Conditions Treated by Savella

Fibromyalgia

Drug Category

SSNRI antidepressants

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