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metoprolol

Side Effect Search

Underlined words or phrases provide helpful links to information in wikipedia.org and when moused over often give helpful definitions of the medical terms. Keywords

Metoprolol may cause short-term memory loss (memory loss for events that happened very recently).

Medical Source Information
Yellow highlights indicate symptoms related to short-term memory loss.

Nervous system side effects have included general fatigue in 1% to 10%, dizziness in 1% to 10%, headache in 0.3% to 4.0%, insomnia in 2%, nightmares in 1%, mental confusion, short-term memory loss, and somnolence. Anxiety, nervousness, hallucinations, headache, tinnitus, and paresthesias have been associated with extended release preparations of metoprolol in postmarketing use.

Side Effects to Watch
Watch closely for the following side effects and notify your physician immediately should any of these develop:

Abnormal bruising or signs of bleeding such as bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash (signs of problems with blood clot formation)
weight gain, congestive heart failure, worsening of congestive heart failure or shortness of breath

Lab and Diagnostic Tests
If certain symptoms develop, ask your physician whether you need the following lab tests or other diagnostic tests (if you've not already had them):

monitor for [coronary artery disease|heart disease that involves a blockage of the blood supply to the heart], [decreased oxygen to the heart due to blockage of the coronary arteries|blood vessels that supply the heart], liver problems or chest discomfort/angina
Monitor alkaline phosphatase and lactate dehydrogenase
Blood tests to assess normal clotting - in people who develop signs of bleeding such as abnormal bruising or signs of bleeding including bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash

References

Comparative multicentre study of the tolerability and efficacy of epanolol versus metoprolol in patients with stable angina pectoris. Clark-Turner N Drugs 1989;38:55-60.
Safety and efficacy of metoprolol in the treatment of hypertension in the elderly. LaPalio L, Schork A, Glasser S, Tifft C J Am Geriatr Soc 1992;40:354-8.
A betablocker nightmare. St George IM N Z Med J 1983;04/13/83:268.
Safety and tolerability of metoprolol OROS in hypertension treatment. Feliciano N, Kasarjian PH, McMillen JI, et al Am Heart J 1990;120:490-4.
Sleep disturbances in hypertension: a double-blind study between isradipine and metoprolol. Kantola I, Rauhala E, Erkinjuntti M, Mansury L J Cardiovasc Pharmacol 1991;18:s41-5.
Analysis of adverse effects among patients with essential hypertension receiving an ACE inhibitor or a beta-blocker. Rosenthal J, Bahrmann H, Benkert K, Baumgart P, Bonner G, Klein G, Neiss A, Schnelle K, Frohlich ED Cardiology 1996;87:409-14.
Metoprolol: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related c. Benfield P, Clissold SP, Brogden RN Drugs 1986;31:376-429.
Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. Plosker GL, Clissold SP Drugs 1992;43:382-414.
Beta-blocker effects on sexual function in normal males. Rosen RC, Kostis JB, Jekelis AW Arch Sex Behav 1988;17:241-55.
The safety after fifty evaluation trial: evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age. Rich MW, LaPalio L, Schork A Am Heart J 1988;116:301-4.
Atenolol and metoprolol: comparison of effects on blood pressure and serum lipoproteins, and side effects. Rossner S, Weiner L Eur J Clin Pharmacol 1983;24:573-7.
Depressed melatonin secretion in patients with nightmares due to beta-adrenoceptor blocking drugs. Brismar K, Mogensen L, Wetterberg L Acta Med Scand 1987;221:155-8.
Atenolol 50 mg or metoprolol 200 mg: a comparison of antihypertensive efficacy, side effects and lipoprotein changes. Weiner L, Rossner S Acta Med Scand 1983;677:153-7.
Product Information. Lopressor (metoprolol). Anonymous Novartis Pharmaceuticals, East Hanover, NJ. PROD;
A general-practice study of the efficacy and tolerability of metoprolol in mild essential hypertension. Frewin DB, Lloyd BL, MacDonald GJ, et al Med J Aust 1988;148:31-5.

Multum version: 154.0 (Jun 16, 2010)

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