
User Reviews \| Add Review \| Search Reviews	Drug Search

You have entered 0 Drug(s) and 0 Symptom(s)

Click Evaluate for a complete analysis of your drugs and symptoms

Prilosec (omeprazole)

Side Effect Search

Underlined words or phrases provide helpful links to information in wikipedia.org and when moused over often give helpful definitions of the medical terms. Keywords

Prilosec may cause vomiting in 1.5% to 3.2% of people. This symptom may occur with a history of zollinger-ellison syndrome.

This drug may also cause the following symptoms that are related to vomiting:

Medical Source Information
Yellow highlights indicate symptoms related to vomiting.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Other less serious side effects are more likely to occur, such as: stomach pain, gas; nausea, vomiting, diarrhea; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gastrointestinal side effects have included diarrhea (3.0% to 3.7%), abdominal pain (2.4%), nausea (2.2% to 4%), vomiting (1.5% to 3.2%), constipation (1.1%), anorexia, irritable colon, flatulence, dry mouth, esophageal candidiasis, and persistent achlorhydria in a Zollinger-Ellison patient. Gastric polyps, hyperplasia of gastric enterochromaffin-like cells, and atrophic gastritis have been reported after long-term therapy. Campylobacter gastroenteritis has been identified in one case-control study. Rare cases of pancreatitis, some fatal, have been reported during the post marketing period.

Hepatic side effects have included elevations in serum transaminases, alkaline phosphatase, bilirubin, and rare cases of hepatitis and hepatic encephalopathy. Fatal fulminant hepatic failure attributed to omeprazole has also been reported.

A 62-year-old man with erosive esophagitis developed signs and symptoms of hepatic disease 17 days after the start of therapy with omeprazole 20 mg per day. Five days after presentation, the patient died from complications associated with fulminant hepatic failure. Autopsy findings included massive central zone necrosis and hemorrhage with proliferation of bile ducts.

Proton pump inhibitors may interfere with the detection of H. pylori by the urea breath test. Therefore, testing for H. pylori with the urea breath test is not recommended in patients who have received proton pump inhibitors in the preceding two weeks.

When omeprazole is given together with clopidogrel, the effectiveness of the clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots may not get the full effect of this medication if they are also taking omeprazole. Separating the dose of clopidogrel and omeprazole at different times of the day does not reduce this drug interaction.

Nervous system side effects have included headache, dizziness, somnolence, vertigo, hemifacial dysesthesia and numbness, paresthesias of the extremities, and a report of reversible gait ataxia.

Renal side effects have included elevations in serum creatinine, rare reports of interstitial nephritis, and renal failure.

Lab and Diagnostic Tests
If certain symptoms develop, ask your physician whether you need the following lab tests or other diagnostic tests (if you've not already had them):

Monitor blood tests

References

Proton pump inhibitor-associated gastric polyps: A retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics. Choudhry U, Boyce HW, Coppola D Am J Clin Pathol 1998;110:615-21.
Long-term treatment with omeprazole for refractory reflux esophagitis: efficacy and safety. Klinkenbergknol EC, Festen HPM, Jansen JBMJ, Lamers CBHW, Nelis F, Snel P, Luckers A, Dekkers CPM, Havu N, Meuwissen M Ann Intern Med 1994;121:161-7.
Efficacy and safety of omeprazole in the long-term treatment of peptic ulcer and reflux oesophagitis resistant to ranitidine. Brunner GH, Lamberts R, Creutzfeldt W Digestion 1990;47:64-8;.
Atrophic gastritis and helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. Kuipers EJ, Lundell L, Klinkenbergknol EC, Havu N, Festen HPM, Liedman B, Lamers CBHW, Jansen JBMJ, Dalenback J, Snel P, N Engl J Med 1996;334:1018-22.
Gastric polyposis: onset during long-term therapy with omeprazole . Graham JR Med J Aust 1992;157:287-8.
Omeprazole, hypergastrinemia, and gastric carcinoid tumors. Freston JW Ann Intern Med 1994;121:232-3.
Development of sustained achlorhydria in a patient with the Zollinger- Ellison syndrome treated with omeprazole [published erratum appears in Gastroenterology 1992 Mar;102(3):1096]. Griffith JL, Cummings OW, Hirschowitz BI Gastroenterology 1991;101:242-6.
Product Information. Prilosec (omeprazole). Anonymous Merck & Co, Inc, West Point, PA. PROD;
Omeprazole and dry mouth. Teare JP, Spedding C, Whitehead MW, Greenfield SM, Challacombe SJ, Thompson RPH Scand J Gastroenterol 1995;30:216-8.
Oesophageal candidiasis after omeprazole therapy. Larner AJ, Lendrum R Gut 1992;33:860-1.
Omeprazole as a cause of oral candidiasis. Anderson PC Arch Dermatol 1995;131:965-6.

Multum version: 154.0 (Jun 16, 2010)

Add a User Review

To add a User Review fill out the fields below. A drug name is required to post. You will be asked to enter the dosage, which is listed on the bottle/container, along with units such as mg, ounces, etc; as well as how often you take the drug. When you enter a possible side effect, you will be asked about its severity. In the comment field, please describe your experiences or any comment that you will think help other users understand what they can expect from their drug treatment. We also welcome comments and suggestions about our site through feedback.

* Enter drug name- enter one drug at a time, by typing at least 3 letters of the drug name and select the appropriate drug from the list, then proceed to entering the next drug. Google

* Enter condition name - the "condition" is the reason you are taking the drug, which could be a disease such as "diabetes" or a symptom such as "joint aches". Enter a condition and select from the list shown, then enter the next condition if you are experiencing more than one.

* Enter side effects - these are any undesirable effects you might be experiencing from the drug(s). Enter your side effect and select from the list shown, then enter the next side effect if you are experiencing more than one. If you are not experiencing any side effects check the box below, No Side Effects.

No Side Effects

Enter comments - tell the community about your experiences and any information you may have about taking these drugs.

Age Gender:

Thank you for adding your review.

Return to Current Page

To help protect against automated posting, please enter the words that appear in the box below (more info).
Words should be separated by space.

Unable to see the image? (get another image)

* Required fields

NOTE: Just because a drug or combination of drugs can cause a symptom does not mean it is actually causing your symptom. Symptoms can be caused by medical conditions as well. Make sure that your physician is aware of any symptoms you are experiencing so he/she can work with you to determine the cause. Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: Please note that the information DoubleCheckMD.com provides is intended to help individuals to work with their medical professionals and is for educational purposes only. It does not constitute medical or healthcare advice and serves to supplement, not substitute for, the expertise and judgment of a healthcare professional. In all cases individuals should consult with a physician before taking any action based on DoubleCheckMD feedback including, but not limited to ceasing taking any drug, changing diet or commencing or discontinuing any course of treatment. The information provided by DoubleCheckMD.com is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that the use of a particular drug is safe, appropriate or effective.