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Altace (ramipril)

Side Effect Search

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Altace may cause itching.

This drug may also cause the following symptoms that are related to itching:

Allergic reactions

Medical Source Information
Yellow highlights indicate symptoms related to itching.

Hypersensitivity reactions to angiotensin converting enzyme (ACE) inhibitors may be life threatening. Angioedema of the face, extremities, lips, tongue, glottis and/or pharynx have been reported rarely in patients receiving ACE inhibitors. In addition, intestinal angioedema has been reported in patients treated with ACE inhibitors. It is recommended that any patient with dyspnea, dysphagia, or significant facial angioedema stop therapy immediately and avoid ACE inhibitor therapy in general. Dermatitis, pruritus, and photosensitivity have also been reported.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: feeling light-headed, fainting; urinating less than usual, or not at all; fever, chills, body aches, flu symptoms; pale skin, easy bruising or bleeding, unusual weakness; pounding or uneven heartbeats; slow heart rate, weak pulse, muscle weakness, tingly feeling; jaundice (yellowing of the skin or eyes); chest pain; or swelling, rapid weight gain. Less serious side effects may include: cough; dizziness, drowsiness, headache; sleep problems (insomnia); decreased sex drive, impotence, or difficulty having an orgasm; nausea, vomiting; or mild skin itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side Effects to Watch
Watch closely for the following side effects and notify your physician immediately should any of these develop:

Abnormal bruising or signs of bleeding such as bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash (signs of problems with blood clot formation)

Lab and Diagnostic Tests
If certain symptoms develop, ask your physician whether you need the following lab tests or other diagnostic tests (if you've not already had them):

Monitor angiotensin converting enzyme and white blood cell count
Blood tests to assess normal clotting - in people who develop signs of bleeding such as abnormal bruising or signs of bleeding including bleeding from the gums, nose, digestive tract, vagina (females), faintness, dizziness, loss of consciousness, or rash

References

Myalgia and arthralgia associated with enalapril and ramipril. Peppers MP Am J Health Syst Pharm 1995;52:203-4.
Study of the efficacy and safety of the combination ramipril 2.5 mg plus hydrochlorothiazide 12.5 mg in patients with mild-to-moderate hypertension. Genthon R, Rangoonwala B, Andrieuxlaclaveline A, Arnaud J, Ballade M, Billou J, Bosredon A, Boutges B, Dubon T, Goigoux B, Lalanne Int J Clin Pharmacol Res 1994;14:1-9.
Angioedema caused by ramipril. Gonzalo FE, Montagut LB, Vecina ST Ann Pharmacother 1995;29:431-2.
ACE inhibitor use and severe angioedema. Murray A, Crowther J Postgrad Med J 1998;74:571-2.
Angioneurotic edema as a reaction to angiotensin-converting enzyme inhibitors. Gunkel AR, Thurner KH, Kanonier G, Sprinzl GM, Thumfart WF Am J Otolaryngol 1996;17:87-91.
Product Information. Altace (ramipril). Anonymous Hoechst Marion-Roussel Inc, Kansas City, MO. PROD;
Ramipril: an updated review of its therapeutic use in essential hypertension and heart failure. Framptom JE, Peters DH Drugs 1995;49:440-66.
The CARE study: a postmarketing evaluation of ramipril in 11,100 patients. Kaplan NM Clin Ther 1996;18:658-70.

Multum version: 154.0 (Jun 16, 2010)

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