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Slow heart rate (usually slower than 60 beats per minute in adults)
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Aspirin
may cause the following symptoms that are related to slow heart rate:- Changes in electrical activity of the heart. This symptom may occur with a high dose/overdose of aspirin-containing products
- Extra heartbeats. This symptom may occur with a high dose/overdose of aspirin-containing products
- Increased free T4
- Premature ventricular contractions. This symptom may occur with a high dose/overdose of aspirin-containing products
- Fast pulse/rapid heart rate (single case). This symptom may occur with a/an dose of 1500 milligram(s) a day or greater
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Note: Original Source for Medical Professionals
Cardiovascular side effects have included salicylate-induced variant angina, ventricular ectopy, conduction abnormalities, and hypotension, particularly during salicylate toxicity. In addition, at least one case of fluid retention simulating acute congestive heart failure has been reported during aspirin therapy. Antiplatelet therapy has also been associated with acute deterioration of intracerebral hemorrhage. A 29-year-old female with a history of migraine developed chest pain, tachycardia and orthopnea following aspirin consumption at doses of 1500 mg per day for several days. After discontinuation of aspirin therapy, the patient's symptoms promptly resolved. The patient consented to a pharmacological challenge test which once again triggered the symptoms. Metabolic side effects have included dehydration and hyperkalemia. Respiratory alkalosis and metabolic acidosis, particularly during salicylate toxicity, have been reported. A case of hypoglycemia has been reported in a patient on hemodialysis. Salicylates have also been reported to displace triiodothyronine (T3) and thyroxine (T4) from protein binding sites. The initial effect is an increase in serum free T4 concentrations.
REFERENCE +
- Individualizing aspirin therapy for prevention of cardiovascular events. Boissel JP JAMA 1998;280:1949-50.
- Aspirin and other platelet-active drugs: the relationship among dose, effectiveness, and side effects. Hirsh J, Dalen JE, Fuster V, Harker LB, Patrono C, Roth G Chest 1995;108 Suppl:s247-57.
- Low-dose aspirin interactions. Neafsey PJ Home Healthc Nurse 2004;22:54-5.
- Salicylate-induced variant angina. Al-Abbasi AH Am Heart J 1983;106:1450.
- Product Information. Bayer aspirin (aspirin). Anonymous Bayer, West Haven, CT. PROD;
- Cardiac conduction abnormalities and atrial arrhythmias associated with salicylate toxicity. Mukerji V, Alpert MA, Flaker GC, Beach CL, Weber RD Pharmacotherapy 1986;6:41-3.
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Slowed heart rate
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Aspirin
may cause the following symptoms that are related to slowed heart rate:- Changes in electrical activity of the heart. This symptom may occur with a high dose/overdose of aspirin-containing products
- Extra heartbeats. This symptom may occur with a high dose/overdose of aspirin-containing products
- Increased free T4
- Premature ventricular contractions. This symptom may occur with a high dose/overdose of aspirin-containing products
- Fast pulse/rapid heart rate (single case). This symptom may occur with a/an dose of 1500 milligram(s) a day or greater
Hide SOURCE +
Note: Original Source for Medical Professionals
Cardiovascular side effects have included salicylate-induced variant angina, ventricular ectopy, conduction abnormalities, and hypotension, particularly during salicylate toxicity. In addition, at least one case of fluid retention simulating acute congestive heart failure has been reported during aspirin therapy. Antiplatelet therapy has also been associated with acute deterioration of intracerebral hemorrhage. A 29-year-old female with a history of migraine developed chest pain, tachycardia and orthopnea following aspirin consumption at doses of 1500 mg per day for several days. After discontinuation of aspirin therapy, the patient's symptoms promptly resolved. The patient consented to a pharmacological challenge test which once again triggered the symptoms. Metabolic side effects have included dehydration and hyperkalemia. Respiratory alkalosis and metabolic acidosis, particularly during salicylate toxicity, have been reported. A case of hypoglycemia has been reported in a patient on hemodialysis. Salicylates have also been reported to displace triiodothyronine (T3) and thyroxine (T4) from protein binding sites. The initial effect is an increase in serum free T4 concentrations.
REFERENCE +
- Individualizing aspirin therapy for prevention of cardiovascular events. Boissel JP JAMA 1998;280:1949-50.
- Aspirin and other platelet-active drugs: the relationship among dose, effectiveness, and side effects. Hirsh J, Dalen JE, Fuster V, Harker LB, Patrono C, Roth G Chest 1995;108 Suppl:s247-57.
- Low-dose aspirin interactions. Neafsey PJ Home Healthc Nurse 2004;22:54-5.
- Salicylate-induced variant angina. Al-Abbasi AH Am Heart J 1983;106:1450.
- Product Information. Bayer aspirin (aspirin). Anonymous Bayer, West Haven, CT. PROD;
- Cardiac conduction abnormalities and atrial arrhythmias associated with salicylate toxicity. Mukerji V, Alpert MA, Flaker GC, Beach CL, Weber RD Pharmacotherapy 1986;6:41-3.
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