|
|
Confusion/disorientation
|
Pepcid AC Maximum Strength (famotidine)
may cause confusion/disorientation.This drug may also cause the following symptoms that are related to confusion/disorientation: - Delirium. This symptom may occur in elderly people with more than one significant medical problem
- Depression
Hide SOURCE +
Note: Original Source for Medical Professionals
Nervous system side effects have included headache (1% to 4.7%) and dizziness (1.3%). Grand mal seizures, paresthesia, and somnolence have been reported infrequently. Lethargy, confusion, psychosis, and agitation have been reported. Delirium has been reported, which reversed upon drug withdrawal. Convulsions, in patients with impaired renal function, have been reported very rarely. Confusion, lethargy, delirium, psychosis, agitation, seizures and somnolence have been reported, particularly in elderly patients and patients with multiple medical problems. The frequency of such reactions may be greater than previously believed. The FDA has accumulated 72 reported cases of such central nervous system reactions. All H2-blockers cross the blood-brain barrier and are found in the cerebrospinal fluid. Psychiatric side effects including depression, anxiety, insomnia, hallucinations, and decreased libido have been reported. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using famotidine and call your doctor at once if you have a serious side effect such as:
easy bruising or bleeding;
fast or pounding heartbeat;
confusion, hallucinations, seizure;
numbness or tingly feeling; or
jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
nausea, vomiting, diarrhea, constipation;
dry mouth;
dizziness, weakness, mood changes;
headache; or
muscle cramps, joint pain.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
REFERENCE +
- Safety profile of H2-receptor antagonists: current status of famotidine. Levine JB J Int Med Res 1989;17 Suppl 1:a48-53.
- Central nervous system reactions to histamine-2 receptor blockers. Cantu TG, Korek JS Ann Intern Med 1991;114:1027-34.
- Famotidine-associated central nervous system reactions and plasma and cerebrospinal drug concentrations in neurosurgical patients with renal failure. Yoshimoto K, Saima S, Echizen H, Nakamura Y, Kondo T, Yagishita Y, Ishizaki T Clin Pharmacol Ther 1994;55:693-700.
- Famotidine-associated mental status changes. Rodgers PT, Brengel GR Pharmacotherapy 1998;18:404-7.
- Product Information. Pepcid (famotidine). Anonymous Merck & Co, Inc, West Point, PA. PROD;
- Delirium following a switch from cimetidine to famotidine. Yuan RY, Kao CR, Sheu JJ, Chen CH, Ho CS Ann Pharmacother 2001;35:1045-8.
- Central nervous system reactions associated with famotidine: Report of five cases. Odeh M, Oliven A J Clin Gastroenterol 1998;27:253-4.
- H-2 blocker delirium. Picotte-Pillmayer D, DiMaggio JR, Baile WF Psychosomatics 1995;36:74-7.
- Famotidine-associated delirium - a series of six cases. Catalano G, Catalano MC, Alberts VA Psychosomatics 1996;37:349-55.
|
|
|
|
Depression/mood changes
|
Pepcid AC Maximum Strength (famotidine)
may cause the following symptoms that are related to depression/mood changes:- Depression.
- Mood disturbances
Hide SOURCE +
Note: Original Source for Medical Professionals
Psychiatric side effects including depression, anxiety, insomnia, hallucinations, and decreased libido have been reported. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using famotidine and call your doctor at once if you have a serious side effect such as:
easy bruising or bleeding;
fast or pounding heartbeat;
confusion, hallucinations, seizure;
numbness or tingly feeling; or
jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
nausea, vomiting, diarrhea, constipation;
dry mouth;
dizziness, weakness, mood changes;
headache; or
muscle cramps, joint pain.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
REFERENCE +
- Product Information. Pepcid (famotidine). Anonymous Merck & Co, Inc, West Point, PA. PROD;
|
|